| 货号 | 15548-100mg |
| 描述 | Ramosetron is a potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3(Ki = 0.06 nM).1,2 It has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors.1 Ramosetron competitively blocks serotonin-mediated contraction of the colon.1 It has applications in ameliorating diarrhea-predominant inflammatory bowel syndrome and postoperative nausea and vomiting.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Miyata, K.,Kamato, T.,Nishida, A., et al. Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]- 4,5,6,7-tetrahydro-1H-benzimidazol hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue. Journal of Pharmacology and Experimental Therapeutics 259(1), 15-21 (1991). 2.Manning, D.D.,Cioffi, C.L.,Usyatinsky, A., et al. Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome. Bioorganic & Medicinal Chemistry Letters 21(1), 58-61 (2011). 3.Manabe, N.,Rao, A.S.,Wong, B.S., et al. Emerging pharmacologic therapies for irritable bowel syndrome. Curr.Gastroenterol.Rep. 12(5), 408-416 (2010). 4.Mihara, T.,Tojo, K.,Uchimoto, K., et al. Reevaluation of the effectiveness of ramosetron for preventing postoperative nausea and vomiting: A systematic review and meta-analysis. Anesthesia and Analgesia 117(2), 329-339 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 315.8 |
| 分子式 | C17H17N3O • HCl |
| CAS号 | 132907-72-3 |
| 稳定性 | ≥ 2 years |
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