ML-213
货号：
15185-50mg 基本售价：
6160.0 元 规格：
50 mg
产品信息
概述| 货号 | 15185-50mg |
| 描述 | The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are predominantly expressed in the peripheral and central nervous system, including hippocampal cells, cortical cells, and dorsal root ganglion. ML-213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) channels (EC50s = 230 and 510 nM for KCNQ2 and KCNQ4, respectively) that demonstrates > 80-fold selectivity against other related K+channels.1 |
| 别名 | CID-3111211; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, H.,Wu, M.,Townsend, S.D., et al. Discovery, synthesis, and structure-activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2(10), 572-577 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 257.4 |
| 分子式 | C17H23NO |
| CAS号 | 489402-47-3 |
| 稳定性 | ≥ 2 years |
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