JC-1
货号：
15003-10mg 基本售价：
6160.0 元 规格：
10 mg
产品信息
概述| 货号 | 15003-10mg |
| 描述 | JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis.1,2,3 It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry.3 A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers).2,3 JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers. |
| 别名 | CBIC2;NK 1420; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Abdalah, R.,Wei, L.,Francis, K., et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neuroscience Letters 405, 68-73 (2006).
2.Petit, P.X.,Lecoeur, H.,Zorn, E., et al. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. Journal of Cell Biology 130(1), 157-167 (1995).
3.Salvioli, S.,Ardizzoni, A.,Franceschi, C., et al. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess Δψ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis. FEBS Letters 411, 77-82 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 652.2 |
| 分子式 | C25H27Cl4N4 • I |
| CAS号 | 3520-43-2 |
| 稳定性 | ≥ 2 years |
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