| 货号 | 11838-100mg |
| 描述 | X-Linked inhibitor of apoptosis (XIAP) is a protein which modulates several pathways, including several related to apoptosis.1 Embelin is a natural benzoquinone, isolated from plants of the genus Embelia, which directly binds and inhibits XIAP (IC50 = 4.1 μM).2 In this way, this cell-permeable inhibitor blocks growth while activating caspases and promoting apoptosis in cancer cells expressing high levels of XIAP.2 Presumably in an XIAP-dependent fashion, embelin (15-50 μM) also prevents NF-κB activation by inhibiting IKK.3,4 This compound also protects against XIAP- and caspase-dependent inflammation.5,6 |
| 别名 | NSC 91874; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Galbán, S., and Duckett, C.S. XIAP as a ubiquitin ligase in cellular signaling. Cell Death and Differentiation 17, 54-60 (2010). 2.Nikolovska-Coleska, Z.,Xu, L.,Hu, Z., et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. Journal of Medicinal Chemistry 47, 2430-2440 (2004). 3.Ahn, K.S.,Sethi, G., and Aggarwal, B.B. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene products. Molecular Pharmacology 71(1), 209-219 (2007). 4.Reuter, S.,Prasad, S.,Phromnoi, K., et al. Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway. Molecular Cancer Research 8(10), 1425-1436 (2010). 5.Mareninova, O.A.,Sung, K.F.,Hong, P., et al. Cell death in pancreatitis: Caspases protect from necrotizing pancreatitis. The Journal of Biological Chemisty 281(6), 3370-3381 (2006). 6.Thippeswamy, B.S.,Meahendran, S.,Biradar, M.I., et al. Protective effect of embelin against acetic acid induced ulcerative colitis in rats. European Journal of Pharmacology 654, 100-105 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 294.4 |
| 分子式 | C17H26O4 |
| CAS号 | 550-24-3 |
| 稳定性 | ≥ 2 years |
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