Phthalazinone pyrazole
货号：
10735-10mg 基本售价：
6160.0 元 规格：
10 mg
产品信息
概述| 货号 | 10735-10mg |
| 描述 | Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis.1 Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors.2 Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM).3 It does not inhibit Aurora B kinase at doses up to 100 μM.3 Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moore, A.S.,Blagg, J.,Linardopoulos, S., et al. Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia 24(4), 671-678 (2010).
2.Yan, A.,Wang, L.,Xu, S., et al. Aurora-A kinase inhibitor scaffolds and binding molecules. Drug Discovery Today 16(5-6), 260-269 (2011).
3.Prime, M.,Courtney, S.M.,Frederick, A.B., et al. Phthalazinone pyrazoles as potent, selective and orally bioavailable inhibitor of Aurora-A kinase. Journal of Medicinal Chemistry 54, 312-3191 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 317.4 |
| 分子式 | C18H15N5O |
| CAS号 | 880487-62-7 |
| 稳定性 | ≥ 2 years |
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