| 货号 | 10492-10mg |
| 描述 | LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 µM.1 It prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged mice.1,2 LP-533401 has also been used to elucidate the role of gut-derived serotonin in pulmonary hypertension and leukemia in mice.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yadav, V.K.,Baliahi, S.,Suresh, P.S., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010). 2.Inose, H.,Zhou, B.,Yadav, V.K., et al. Efficacy of serotonin inhibition in mouse models of bone loss. J. Bone Miner. Res. 26(9), 2002-2011 (2011). 3.Abid, S.,Houssaini, A.,Chevarin, C., et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 303(6), L500-508 (2012). 4.Krevvata, M.,Silva, B.C.,Manavalan, J.S., et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood 124(18), 2834-2846 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 526.5 |
| 分子式 | C27H22F4N4O3 |
| CAS号 | 945976-43-2 |
| 稳定性 | ≥ 2 years |
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