Amidepsine A
货号：
17774-2.5mg 基本售价：
6132.0 元 规格：
2.5 mg
产品信息
概述| 货号 | 17774-2.5mg |
| 描述 | Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 10.2 µM in rat liver microsomes).1 It inhibits triacylglycerol formation in Raji cells with an IC50 value of 15.5 µM.1 |
| 别名 | FO-2942A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tomoda, H.,Ito, M.,Tabata, N., et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. J.Antibiot.(Tokyo) 48(9), 937-941 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 567.5 |
| 分子式 | C29H29NO11 |
| CAS号 | 169181-28-6 |
| 稳定性 | ≥ 2 years |
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