| 货号 | 17547-25mg |
| 描述 | Monoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects.1,2,3 In particular, MAGs containing docosahexaenoic acid (Item No. 90310) or eicosapentaenoic acid (EPA; Item No. 90110) have anti-proliferative properties against colon and lung cancer cell lines.4 Eicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 µM.5 It is an analog of eicosapentaenoyl ethanolamide (Item No. 10964), a natural N-acylethanolamide that impacts aging and inflammation.6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hernández-Torres, G.,Cipriano, M.,Hedén, E., et al. A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis. Angewandte Chemistry International Edition English 53(50), 13765-13770 (2014). 2.Douglass, J.D.,Zhou, Y.X.,Wu, A., et al. Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity. Journal of Lipid Research 56(6), 1153-1171 (2015). 3.Morin, C.,Blier, P.U. and Fortin, S. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. Arthritis Research & Therapy 17, (2015). 4.Morin, C.,Rousseau, É. and Fortin, S. Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 89(4), 203-213 (2013). 5.Tremblay, H.,St-Georges, C.,Legault, M.A., et al. One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters 24(24), 5635-5638 (2014). 6.Lucanic, M.,Held, J.M.,Vantipalli, M.C., et al. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature 473(7346), 226-229 (2011). 7.Balvers, M.G.,Verhoeckx, K.C.,Plastina, P., et al. Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties. Biochimica et Biophysica Acta 1801(10), 1107-1114 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 359.6 |
| 分子式 | C23H37NO2 |
| CAS号 | 1638355-66-4 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |