| 货号 | 3259/50 |
| 别名 | (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride |
| 供应商 | Tocris |
| 生物活性 | Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 299.66 |
| 分子式 | C9H11F2N3O4.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| CAS号 | 122111-03-9 |
| 参考文献 | Heinemannet al (1995) Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin.Oncol. 22 (Suppl. 11) 11. PMID: 7481839. Plunkettet al (1995) Preclinical characteristics of gemcitabine. Anticancer Drugs 6 (Suppl. 6) 7. PMID: 8718419. Hertelet al (1990) Evaluation of the antitumor activity of Gemcitabine (2',2'-Difluoro-2'-deoxycytidine). Cancer Res. 50 4417. PMID: 2364394. |