| 货号 | 9001881-50mg |
| 描述 | D,L-O-Desmethyl venlafaxine is the active metabolite of venlafaxine (Item No. 11567), an inhibitor of the reuptake of both serotonin and norepinephrine.1,2,3 Venlafaxine is metabolized by cytochrome P450 2D6, yielding O-desmethyl venlafaxine, which is pharmacologically similar to the parent drug.4,5 D,L-O-Desmethyl venlafaxine inhibits the human serotonin and norepinephrine transporters with IC50 values of 47.3 and 531.3 nM, respectively.6 |
| 别名 | Desvenlafaxine;DVS 233;MDD-XR; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liu, M.,Sun, Y.,Zhao, S., et al. A novel prodrug strategy to improve the oral absorption of O-desmethylvenlafaxine. Exp. Ther. Med. 12(3), 1611-1617 (2016). 2.Yardley, J.P.,Husbands, G.E.M.,Stack, G., et al. 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity. Journal of Medicinal Chemistry 33(10), 2899-2905 (1990). 3.Bymaster, F.P.,Dreshfield-Ahmad, L.J.,Threlkeld, P.G., et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25(6), 871-880 (2001). 4.Otton, S.V.,Ball, S.E.,Cheung, S.W., et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br. J. Clin. Pharmacol. 41(2), 149-156 (1996). 5.Owens, M.J.,Neal, W.,Plott, S.J., et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J. Pharmacol. Exp. Ther. 283(3), 1305-1322 (1997). 6.Deecher, D.C.,Beyer, C.E.,Johnston, G., et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J. Pharmacol. Exp. Ther. 318(2), 657-665 (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 263.4 |
| 分子式 | C16H25NO2 |
| CAS号 | 93413-62-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |