| 货号 | 9000249-50mg |
| 描述 | L-165,041 is a potent and selective agonist of the nuclear receptor PPARβ/δ (Ki = 9 nM, EC50 = ~500 nM for hPPARβ/δ).1,2 It is less effective against PPARα and PPARγ, with activity at those receptors depending on cell type and system of study.2,3,4 L-165,041 is used to evaluate the diverse roles of PPARβ/δ, including those related to cholesterol metabolism, inflammation, and neuroprotection.2,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berger, J.,Leibowitz, M.D.,Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. The Journal of Biological Chemisty 274, 6718-6725 (1999). 2.Willson, T.M.,Brown, P.J.,Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. Journal of Medicinal Chemistry 43(4), 528-550 (2000). 3.Porcelli, L.,Gilardi, F.,Laghezza, A., et al. Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. Journal of Medicinal Chemistry 55(1), 37-54 (2012). 4.Basséne, C.E.,Suzenet, F.,Hennuyer, N., et al. Studies towards the conception of new selective PPARβ/δ ligands. Bioorganic & Medicinal Chemistry Letters 16(17), 4528-4532 (2006). 5.Iwashita, A.,Muramatsu, Y.,Yamazaki, T., et al. Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics 320(3), 1087-1096 (2007). 6.Leibowitz, M.D.,Fiévet, C.,Hennuyer, N., et al. Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Letters 473(3), 333-336 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.4 |
| 分子式 | C22H26O7 |
| CAS号 | 79558-09-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |