| 货号 | 11638-50mg |
| 描述 | Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.1,2 Indiplon is selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5(EC50 = 24, 60, and 77 nM).1,2 Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.3,4 |
| 别名 | NBI 34060; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Petroski, R.E.,Pomeroy, J.E.,Das, R., et al. Indiplon is a high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABAA receptors. Journal of Pharmacology and Experimental Therapeutics 317(1), 369-377 (2006). 2.Sullivan, S.K.,Petroski, R.E.,Verge, G., et al. Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor. Journal of Pharmacology and Experimental Therapeutics 311(2), 537-546 (2004). 3.Foster, A.C.,Pelleymounter, M.A.,Cullen, M.J., et al. In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. Journal of Pharmacology and Experimental Therapeutics 311(2), 547-559 (2004). 4.Scharf, M.B.,Black, J.,Hull, S., et al. Long-term nightly treatment with indiplon in adults with primary insomnia: Results of a double-blind, placebo-controlled, 3-month study. Sleep 30(6), 743-752 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 376.4 |
| 分子式 | C20H16N4O2S |
| CAS号 | 325715-02-4 |
| 稳定性 | ≥ 2 years |
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