Prostaglandin A2 methyl ester
货号：
9000185-10mg 基本售价：
6048.0 元 规格：
10 mg
产品信息
概述| 货号 | 9000185-10mg |
| 描述 | Prostaglandin A2(PGA2) is a naturally occurring PG in gorgonian corals where it may function in self defense. At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at G1 and G2/M by preventing activation of cyclin-dependent kinases.1 At similar concentrations, it stabilizes transcripts for the tumor suppressor SMAR1, downregulating cyclin D1 expression.2PGA2 also induces apoptosis in HL-60 cells.3 Prostaglandin A2 methyl ester is a lipophilic analog of PGA2 which may be more amenable for certain formulations or applications. Its biological properties have not been evaluated. |
| 别名 | Medullin methyl ester;PGA2 methyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hitomi, M.,Shu, J.,Strom, D., et al. Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. The Journal of Biological Chemisty 271, 9376-9383 (1996).
2.Pavithra, L.,Rampalli, S.,Sinha, S., et al. Stabilization of SMAR1 mRNA by PGA2 involves a stem-loop structure in the 5 UTR. Nucleic Acids Research 35(18), 6004-6016 (2007).
3.Lee, S.Y.,Ahn, J.H.,Ko, K.W., et al. Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells. Prostaglandins & Other Lipid Mediators 91, 30-37 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C21H32O4 |
| CAS号 | 31753-19-2 |
| 稳定性 | ≥ 1 year |
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