| 货号 | 13598-50mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,1 and tumorigenesis.2,3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.4 Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM)4 and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),5 IWR-1-exo has little effect in either assay at 10 μM.4 Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 2.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 3.Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 4.Chen, B.,Dodge, M.E.,Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology 5(2), 100-107 (2009). 5.Lu, J.,Ma, Z.,Hsieh, J.C., et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorganic & Medicinal Chemistry Letters 19, 3825-3827 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.4 |
| 分子式 | C25H19N3O3 |
| CAS号 | 1127442-87-8 |
| 稳定性 | ≥ 2 years |
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