| 货号 | 1667/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective tachykinin NK2 receptor antagonist (pKB values are 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors respectively). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 904.08 |
| 分子式 | C49H61N9O8 |
| 可溶性/溶解性 | Soluble to 4 mg/ml in ethanol |
| CAS号 | 141636-65-9 |
| 序列号 | AAWFPPX (Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide) |
| 参考文献 | Matuszeket al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103. PMID: 9718274. Zagorodnyuket al (1995) Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 115 237. PMID: 7545517. McElroyet al (1992) Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 35 2582. PMID: 1321907. |