Riociguat
货号：
9000554-50mg 基本售价：
5992.0 元 规格：
50 mg
产品信息
概述| 货号 | 9000554-50mg |
| 描述 | Riociguat is a stimulator of soluble guanylate cyclase (sGC). It increases the activity of sGC in vitro by up to 73-fold and acts in synergy with nitric oxide to increase sGC activity up to 122-fold.1 At concentrations up to 10 μM,riociguat does not inhibit cGMP-specific nor cGMP-metabolizing phosphodiesterases, such as PDE1, PDE2, PDE5, or PDE9.1 Riociguat has been shown to promote vasodilation in several pre-clinical animal models of hypertension and has been evaluated in phase II and III clinical studies of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.2 |
| 别名 | BAY 63-2521; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stasch, J.P.,Pacher, P. and Evgenov, O.V. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 123(20), 2263-2273 (2011).
2.Ghofrani, H.A.,Humbert, M.,Langleben, D., et al. Riociguat: Mode of action and clinical development in pulmonary hypertension. Chest S0012-3692(16), 49111-49117 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.4 |
| 分子式 | C20H19FN8O2 |
| CAS号 | 625115-55-1 |
| 稳定性 | ≥ 2 years |
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