ω-Agatoxin IVA (trifluoroacetate salt)
货号：
21605-100ug 基本售价：
5950.0 元 规格：
100 ug
产品信息
概述| 货号 | 21605-100ug |
| 描述 | ω-Agatoxin IVA is a natural peptide first isolated from the venom of funnel spiders.1 It selectively and irreversibly blocks P-type calcium channels (IC50<1 nM), high voltage-activated channels first discovered in Purkinje cells.2,3 ω-Agatoxin IVA also blocks N-type calcium channels at micromolar concentrations.3 |
| 别名 | ω-Aga IVa;SNX-290; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mintz, I.M.,Venema, V.J.,Swiderek, K.M., et al. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature 355(6363), 827-829 (1992).
2.Mori, Y.,Mikala, G.,Varadi, G., et al. Molecular pharmacology of voltage-dependent calcium channels. Jpn. J. Pharmacol. 72(2), 83-109 (1996).
3.Tringham, E.W.,Dupere, J.R.B.,Payne, C.E., et al. Protease treatment of cerebellar Purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA. J. Pharmacol. Exp. Ther. 324(2), 806-814 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 5316.3 |
| 分子式 | C217H360N68O60S10 • CF3COOH |
| 稳定性 | ≥ 2 years |
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