| 货号 | 19891-50mg |
| 描述 | SKQ1 (bromide) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).1 SKQ1 prevents neuronal loss and synaptic damage in a rat model of spontaneous Alzheimer’s disease, as well as decreases severity of arthritic lesions in rats.2,3 SKQ1 slows development of age-related ocular pathologies in murine, porcine, bovine, and canine model systems.4 It also prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction.5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Skulachev, V.P. Cationic antioxidants as a powerful tool against mitochondrial oxidative stress. Biochem. Biophys. Res. Commun. 441(2), 275-279 (2013). 2.Stefanova, N.A.,Muraleva, N.A.,Maksimova, K.Y., et al. An antioxidant specifically targeting mitochondria delays progression of Alzheimer’s disease-like pathology. Aging (Albany NY) 8(11), 2713-2733 (2016). 3.Andreev-Andrievskiy, A.A.,Kolosova, N.G.,Stefanova, N.A., et al. Efficacy of mitochondrial antioxidant plastoquinonyl-decyl-triphenylphosphonium bromide (SkQ1) in the rat model of autoimmune arthritis. Oxid. Med. Cell. Longev. 8703645 (2016). 4.Skulachev, M.V.,Severin, F.F., and Skulachev, V.P. Receptor regulation of senile phenoptosis. Biochemistry (Mosc.) 79(10), 994-1003 (2014). 5.Plotnikov, E.Y.,Chupurkina, A.A.,Jankauskas, S.S., et al. Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion. Biochimica et Biophysica Acta 1812(1), 77-86 (2011). 6.Plotnikov, E.Y.,Morosanova, M.A.,Pevzner, I.B., et al. Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection. Proc. Natl. Acad. Sci. USA 110(33), E3100-E3108 (2013). 7.Skulachev, V.P.,Anisimov, V.N.,Antonenko, Y.N., et al. An attempt to prevent senescence: A mitochondrial approach. Biochim Biophys. Acta. 1787(5), 437-461 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 617.6 |
| 分子式 | C36H42O2P • Br |
| CAS号 | 934826-68-3 |
| 稳定性 | ≥ 1 year |
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