| 货号 | 10007165-100ug |
| 描述 | Leukotriene D4(LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4LTD4 is several hundred fold more potent than LTC4 at the cysteinyl-leukotriene 1 (CysLT1) receptor, but they exhibit approximately equal affinity at the CysLT2receptor.5,6LTD4 methyl ester is a more lipid soluble form of LTD4. The biological activity of LTD4 methyl ester has not been reported. LTD4 methyl ester is a more lipid soluble form of LTD4. The biological activity of LTD4 methyl ester has not been reported. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Örning, L.,Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America 77, 2014-2017 (1980). 2.Hammarström, S.,Örning, L., and Bernström, K. Metabolism of leukotrienes. Molecular and Cellular Biochemistry 69, 7-16 (1985). 3.Hedqvist, P.,Dahlén, S.E.,Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiologica Scandinavica 110, 331-333 (1980). 4.Samuelsson, B.,Dahlén, S.E.,Lindgren, J.Å., et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237, 1171-1176 (1987). 5.Lynch, K.R.,ONeill, G.P.,Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999). 6.Heise, C.E.,ODowd, B.F.,Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 510.7 |
| 分子式 | C26H42N2O6S |
| 稳定性 | ≥ 1 year |
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