| 货号 | 5003/50 |
| 别名 | D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hyd |
| 供应商 | Tocris |
| 生物活性 | Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 394.86 |
| 分子式 | C20H18N6O.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Shanget al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155. PMID: 23382194. Shanget al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699. PMID: 22726684. |