| 货号 | 4858/50 |
| 别名 | 2-[(4-Methylphenyl)sulfonyl]-5-nitr |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 267.26 |
| 分子式 | C11H9NO5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol with gentle warming |
| 参考文献 | Chenget al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079. PMID: 24556694. Pulvinoet al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668. PMID: 22791293. |