| 货号 | 1625/50 |
| 别名 | [(3-Fluorophenyl)methylene]hydrazon |
| 供应商 | Tocris |
| 生物活性 | Novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2 - 5.3 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 244.24 |
| 分子式 | C14H10F2N2 |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 15332-10-2 |
| 参考文献 | Zhanget al (2005) Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 315 1212. PMID: 16135701. O'Brienet al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731. PMID: 12920211. Williamset al (2002) DFB, an allosteric potentiator of mGluR5 4th International Meeting on Metabotropic Glutamat. |