| 货号 | 3305/50 |
| 别名 | N-[3-[(4-Amino-6,7-dimethoxy-2-quin |
| 供应商 | Tocris |
| 生物活性 | Functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 425.91 |
| 分子式 | C19H27N5O4.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 25 mM in DMSO |
| CAS号 | 81403-68-1 |
| 参考文献 | Yamaguchiet al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247. PMID: 16428864. Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426. PMID: 12892027. Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum. BJU Int. 91 873. PMID: 12780851. |