| 货号 | 4406/50 |
| 别名 | 5-[(4-Ethylphenyl)methylene]-2-thio |
| 供应商 | Tocris |
| 生物活性 | Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 249.35 |
| 分子式 | C12H11NOS2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Guoet al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615. PMID: 18509642. Huanget al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480. PMID: 17046567. Yinet al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151. PMID: 13679853. |