| 货号 | 16822-10mg |
| 描述 | Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.2 Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo,3 studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.4 Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides. |
| 别名 | Lat-NEt; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Experimental Eye Research 38, 181-184 (1984). 2.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001). 3.Larrouy, D.,Vidal, H.,Andreelli, F., et al. Cloning and mRNA tissue distribution of human PPARγ coactivator-1. International Journal of Obesity 23, 1327-1332 (1999). 4.Maxey, K.M.,Johnson, J.,Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of Ophthalmology 47(4), 34-40 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.6 |
| 分子式 | C25H39NO4 |
| CAS号 | 607351-44-0 |
| 稳定性 | ≥ 1 year |
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