L189
货号：
18374-50mg 基本售价：
5922.0 元 规格：
50 mg
产品信息
概述| 货号 | 18374-50mg |
| 描述 | L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).1 It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.1 L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, X.,Zhong, S.,Zhu, X., et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Research 68(9), 3169-3177 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 246.3 |
| 分子式 | C11H10N4OS |
| CAS号 | 64232-83-3 |
| 稳定性 | ≥ 2 years |
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