L002
货号：
17778-50mg 基本售价：
5922.0 元 规格：
50 mg
产品信息
概述| 货号 | 17778-50mg |
| 描述 | L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro).1 It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3.1 It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts.1 |
| 别名 | p300/CBP Inhibitor VI;NSC 764414; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, H.,Pinello, C.E.,Luo, J., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Molecular Cancer Therapeutics 12(5), 610-620 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 321.3 |
| 分子式 | C15H15NO5S |
| CAS号 | 321695-57-2 |
| 稳定性 | ≥ 2 years |
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