SAMS Peptide
货号：
17061-5mg 基本售价：
5922.0 元 规格：
5 mg
产品信息
概述| 货号 | 17061-5mg |
| 描述 | AMP-activated protein kinase (AMPK) plays a role in energy metabolism and glucose homeostasis by monitoring the ratio of ATP to AMP. This kinase can inactivate HMG-CoA reductase and acetyl-CoA carboxylase as well as block the activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase (protein kinase A or PKA). SAMS peptide is a synthetic peptide substrate for AMPK based on the sequence around Ser79 (which is phosphorylated exclusively by AMPK) on acetyl-CoA carboxylase.1 In this sequence, Ser77 (which is phosphorylated exclusively by PKA) is replaced by alanine to eliminate a neighboring binding site for PKA.1 This substitution yields a substrate more specific for AMPK than acetyl-CoA carboxylase itself. SAMS peptide is phosphorylated rapidly by AMPK, providing a convenient and sensitive tool for assaying AMPK activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davies, S.P.,Carling, D. and Hardie, D.G. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. European Journal of Biochemistry 186(1-2), 123-128 (1989).
2.Carling, D.,Clarke, P.R.,Zammit, V.A., et al. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. European Journal of Biochemistry 186(1-2), 129-136 (1989).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 1779.2 |
| 分子式 | C74H131N29O18S2 |
| CAS号 | 125911-68-4 |
| 稳定性 | ≥ 2 years |
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