SU 5416
货号：
13342-50mg 基本售价：
5922.0 元 规格：
50 mg
产品信息
概述| 货号 | 13342-50mg |
| 描述 | SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).1,2,3 SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).1 |
| 别名 | NSC 696819;Semaxinib;Sugen 5416;VEGFR 2 Kinase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fong, T.A.T.,Shawver, L.K.,Sun, L., et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Research 59, 99-106 (1999).
2.Litz, J.,Warshamana-Greene, G.S.,Sulanke, G., et al. The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth andangiogenesis, in part by blocking Kit-mediated VEGF expression. Lung Cancer 46, 283-291 (2004).
3.Mologni, L.,Sala, E.,Cazzaniga, S., et al. Inhibition of RET tyrosine kinase by SU5416. Journal of Molecular Endocrinology 37, 199-212 (2006).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 238.3 |
| 分子式 | C15H14N2O |
| CAS号 | 204005-46-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
