| 货号 | 0883/50 |
| 别名 | 1-[2-(3,4-Dichlorophenyl)ethyl]-4-m |
| 供应商 | Tocris |
| 生物活性 | σ1 receptor antagonist, approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1,α2,β adrenoceptor, 5-HT1 and 5-HT2 receptors. Prevents hyperlocomotion following cocaine administration in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 346.13 |
| 分子式 | C13H18Cl2N2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 150208-28-9 |
| 参考文献 | Liuet al (2005) Cocaine up-regulated fra-2 and σ-1 receptor gene and protein expression in brain regions involved in addiction and reward. J.Pharmacol.Exp.Ther. 314 770. PMID: 15879001. McCrackenet al (1999) Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur.J.Pharmacol. 365 35. PMID: 9988120. Matsumotoet al (1995) Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur.J.Pharmacol. 280 301. PMID: 8566098. |