| 货号 | 14463-5mg |
| 描述 | Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases.1,2 Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM.1,3 It also blocks caspase-mediated apoptosis in vivo.4 Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.5 |
| 别名 | Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Xiang, J.,Chao, D.T. and Korsmeyer, S.J. BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proceedings of the National Academy of Sciences of the United States of America 93, 14559-14563 (1996). 2.Garcia-Calvo, M.,Peterson, E.P.,Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273, 32608-32613 (1998). 3.Slee, E.A.,Zhu, H.,Chow, S.C., et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochemistry Journal 315, 21-24 (1996). 4.Künstle, G.,Leist, M.,Uhlig, S., et al. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunology Letters 55(1), 5-10 (1997). 5.Meraz, I.M.,Melendez, B.,Gu, J., et al. Activation of the inflammasome and enhanced migration of microparticle-stimulated dendritic cells to the draining lymph node. Molecular Pharmaceutics 9, 2049-2062 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 467.5 |
| 分子式 | C22H30FN3O7 |
| CAS号 | 187389-52-2 |
| 稳定性 | ≥ 2 years |
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