| 货号 | 15631-50mg |
| 描述 | SCH 23390 is a halobenzazepine that acts as a selective antagonist of the dopamine D1-like receptor subtypes D1 and D5(Kis = 0.2 and 0.3 nM, respectively).1In vivo studies have demonstrated that SCH 23390 can abolish pharmacologically-induced seizures.1 This compound is useful for studying the role of the dopamine system in normal brain function and neurological disorders.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bourne, J.A. SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7(4), 399-414 (2001). 2.Beninger, R.J. and Miller, R. Dopamine D1-like receptors and reward-related incentive learning. Neuroscience and Biobehavioral Reviews 22(2), 335-345 (1998). 3.Oerther, S. and Ahlenius, S. Atypical antipsychotics and dopamine D1 receptor agonism: An in vivo experimental study using core temperature measurements in the rat. Journal of Pharmacology and Experimental Therapeutics 292(2), 731-736 (2000). 4.Patel, S.,Rademacher, D.J. and Hillard, C.J. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. Journal of Pharmacology and Experimental Therapeutics 306(3), 880-888 (2003). 5.Yang, Z.,Asico, L.D.,Yu, P., et al. D5 dopamine receptor regulation of phospholipase D. American Journal of Physiology.Heart and Circulatory Physiology 288, H55-H61 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 324.2 |
| 分子式 | C17H18ClNO • HCl |
| CAS号 | 125941-87-9 |
| 稳定性 | ≥ 2 years |
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