GANT 58
货号：
14193-50mg 基本售价：
5880.0 元 规格：
50 mg
产品信息
概述| 货号 | 14193-50mg |
| 描述 | Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 58 is a GLI antagonist that inhibits GLI1-mediated transcription (EC50 = 5 μM) in a variety of cell types.1,2,3 It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting GLI1 nuclear accumulation.1 GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.2,3 |
| 别名 | NSC 75503; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stanton, B.Z. and Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular BioSystems 6(1), 44-54 (2010).
2.Joo, J.,Christensen, L.,Warner, K., et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One 4(10), (2009).
3.Beauchamp, E.,Bulut, G.,Abaan, O., et al. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. The Journal of Biological Chemisty 284(14), 9074-9082 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392.5 |
| 分子式 | C24H16N4S |
| CAS号 | 64048-12-0 |
| 稳定性 | ≥ 2 years |
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