| 货号 | 2082/1 |
| 别名 | GLP-1 (7-36) amide |
| 供应商 | Tocris |
| 生物活性 | Potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3297.67 |
| 分子式 | C149H226N40O45 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 107444-51-9 |
| 序列号 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modifications: Arg-30 = C-terminal amide) |
| 参考文献 | Perryet al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881. PMID: 12183643. Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717. PMID: 11124853. Turtonet al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69. PMID: 8538742. Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat insulinoma-derived cells. J.Endocrinol. 116 357. PMID: 2832504. |