| 货号 | 2071/1 |
| 别名 | [D-Phe11,His12]-Sauvagine (11-40) |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3650.29 |
| 分子式 | C161H274N48O46S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 220673-95-0 |
| 序列号 | FHLLRKMIEIEKQEKEKQQAANNRLLLDTI (Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide) |
| 参考文献 | Sananbenesiet al (2003) Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J.Neurosci. 23 11436. PMID: 14673008. Braunset al (2001) Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments. Neuropharmacology 41 507. PMID: 11543771. Ruhmannet al (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30. Proc.Natl.Acad.Sci.USA 9515264. |