15-OxoEDE
货号：
37730-250ug 基本售价：
5824.0 元 规格：
250 ug
产品信息
概述| 货号 | 37730-250ug |
| 描述 | 15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.1 A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.2 |
| 别名 | 15-KEDE; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Haviv, F.,Ratajczyk, J.D.,DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. Journal of Medicinal Chemistry 30, 254-263 (1987).
2.Powell, W.S.,Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. The Journal of Biological Chemisty 267, 19233-19241 (1992).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 322.5 |
| 分子式 | C20H34O3 |
| CAS号 | 105835-44-7 |
| 稳定性 | ≥ 1 year |
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