| 货号 | 15207-50mg |
| 描述 | The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation.1,2 A-967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.3 It attenuates cold allodynia following nerve injury without producing locomotor or cardiovascular side effects.3 A-967079 also suppresses neuronal activity in response to mechanical stimulation and diminishes postoperative pain due to mechanical stimuli.4,2 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Klement, G.,Eisele, L.,Malinowsky, D., et al. Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore. Biophysical Journal 104(4), 798-806 (2013). 2.Wei, H.,Karimaa, M.,Korjamo, T., et al. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117(1), 137-148 (2012). 3.Chen, J.,Joshi, S.K.,DiDomenico, S., et al. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152(5), 1165-1172 (2011). 4.McGaraughty, S.,Chu, K.L.,Perner, R.J., et al. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Molecular Pain 6, 14 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 207.3 |
| 分子式 | C12H14FNO |
| CAS号 | 1170613-55-4 |
| 稳定性 | ≥ 2 years |
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