| 货号 | 13174-50mg |
| 描述 | M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM)1 as well as human HDAC1 (IC50 = 46 nM).2 It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1.3 M 344 enhances the sensitivity of human squamous carcinoma cells to radiation4 and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).5 |
| 别名 | D237;Histone Deacetylase Inhibitor III;MS 344; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jung, M.,Brosch, G.,Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. Journal of Medicinal Chemistry 42, 4669-4679 (1999). 2.Remiszewski, S.W.,Sambucetti, L.C.,Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. Journal of Medicinal Chemistry 45(4), 753-757 (2002). 3.Heltweg, B.,Dequiedt, F.,Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. Journal of Medicinal Chemistry 47, 5235-5243 (2004). 4.Zhang, Y.,Jung, M.,Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiation Research 161, 667-674 (2004). 5.Takai, N.,Ueda, T.,Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecologic Oncology 101, 108-113 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 307.4 |
| 分子式 | C16H25N3O3 |
| CAS号 | 251456-60-7 |
| 稳定性 | ≥ 2 years |
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