| 货号 | 9001068-25ug |
| 描述 | FABP4 is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high-affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated.1 Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP4 is composed of ten antiparallel β strands that form a barrel. FABP4 is a fat cell specific protein involved in facilitating the bidirectional flux of fatty acids into and out of the adipocyte in response to insulin and epinephrine.3,4,5 |
| 别名 | Adipocyte FABP;A-FABP;ALBP;aP2;Fatty Acid Binding Protein 4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cellular and Molecular Life Sciences 59, 1096-1116 (2002). 2.Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. Journal of Chromatography B 797, 255-268 (2003). 3.Trillou, C.R.,Arnone, M.,Delgorge, C., et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 284, R345-R353 (2003). 4.Hotamisligil, G.S.,Johnson, R.S.,Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274, 1377-1379 (1996). 5.Uysal, K.T.,Scheja, L.,Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9), 3388-3396 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% (estimated by SDS-PAGE) |
| 稳定性 | ≥ 9 months |
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