Conessine
货号：
11700-250mg 基本售价：
5810.0 元 规格：
250 mg
产品信息
概述| 货号 | 11700-250mg |
| 描述 | Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4.1 Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.1 |
| 别名 | Neriine;NSC 119994;Roquessine;Wrightine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhao, C.,Sun, M.,Bennani, Y.L., et al. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. Journal of Medicinal Chemistry 51, 5423-5430 (2008).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.6 |
| 分子式 | C24H40N2 |
| CAS号 | 546-06-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
