DBeQ
货号：
15318-50mg 基本售价：
5796.0 元 规格：
50 mg
产品信息
概述| 货号 | 15318-50mg |
| 描述 | The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.1 DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM).2 It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM.2 At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.2 |
| 别名 | N,N-Dibenzylquinazoline-2,4-diamine;JRF 12; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chou, T.F. and Deshaies, R.J. Development of p97 AAA ATPase inhibitors. Autophagy 7(9), 1091-1092 (2011).
2.Chou, T.F.,Brown, S.J.,Minond, D., et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proceedings of the National Academy of Sciences of the United States of America 108(12), 4834-4839 (2011).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.4 |
| 分子式 | C22H20N4 |
| CAS号 | 177355-84-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
