Rofecoxib
货号：
10010260-500mg 基本售价：
5796.0 元 规格：
500 mg
产品信息
概述| 货号 | 10010260-500mg |
| 描述 | Rofecoxib is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 activity with 1,000-fold selectivity over that of COX-1 (IC50s = 26 nM and > 50 µM in human osteosarcoma cells).1Inin vivo rodent models, rofecoxib can inhibit carrageenan-induced paw edema (ID50 = 1.5 mg/kg), carrageenan-induced paw hyperalgesia (ID50 = 1.0 mg/kg), lipopolysaccharide-induced pyresis (ID50 = 0.24 mg/kg), and adjuvant-induced arthritis (ID50 = 0.74 mg/kg/day).1 Despite its effectiveness against pain and inflammation, rofecoxib was removed from the market in 2004 due to concerns over its long-term cardiovascular safety.2,3 |
| 别名 | MK 966;Vioxx; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chan, C.C.,Boyce, S.,Brideau, C., et al. Rofecoxib [Vioxx, MK-0966; 4-(4-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. Journal of Pharmacology and Experimental Therapeutics 290(2), 551-560 (1999).
2.Thérien, M.,Gauthier, J.Y.,Leblanc, Y., et al. Synthesis of Rofecoxib, (MK 0966, Vioxxr 4-(4-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2. Synthesis 2001(12), 1778-1779 (2001).
3.Blobaum, A.L., and Marnett, L.J. Structural and functional basis of cyclooxygenase inhibition. Journal of Medicinal Chemistry 50(7), 1425-1441 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.4 |
| 分子式 | C17H14O4S |
| CAS号 | 162011-90-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
