| 货号 | 10007978-100ug |
| 描述 | 13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2receptor.1 It also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4 |
| 别名 | 13,14-dihydro-15-keto PGD2-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rangachari, P.K., and Betti, P.A. Biological activity of metabolites of PGD2 on canine proximal colon. American Journal of Physiology 264, G886-G894 (1993). 2.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001). 3.Liston, T.E., and Roberts, L.J., II. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. The Journal of Biological Chemisty 260, 13172-13180 (1985). 4.Morrow, J.D.,Prakash, C.,Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Analytical Biochemistry 193, 142-148 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 356.5 |
| 分子式 | C20H28D4O5 |
| 稳定性 | ≥ 1 year |
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