| 货号 | 20240-5mg |
| 描述 | Mastoparan is a mast cell degranulating peptide originally isolated from Vespid wasp venom.1 It promotes degranulation by increasing GTPase activity for Gi and Go signaling independent of G protein-coupled receptor binding.2,3 Mastoparan also binds calmodulin (Kd = 0.3 nM) and inhibits the calmodulin-induced activation of phosphodiesterase (IC50 = 0.02 µM).4,5In vitro, mastoparan was effective in killing leukemia, myeloma, and breast cancer cells (IC50s = 8-9.2, 11, and 20-24 µM, respectively).6 It worked synergistically with gemcitabine in a mouse model of mammary carcinoma.6 |
| 别名 | NSC 351907; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hirai, Y.,Yashuhara, T.,Yoshida, H., et al. A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii. Chem. Pharm. Bull. (Tokyo) 27(8), 1942-1944 (1979). 2.Higashijima, T.,Uzu, S.,Nakajima, T., et al. Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). J. Biol. Chem. 263(14), 6491-6494 (1988). 3.Higashijima, T.,Burnier, J. and Ross, E.M. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. J. Biol. Chem. 265(24), 14176-14186 (1990). 4.Malencik, D.A. and Anderson, S.R. High affinity binding of the mastoparans by calmodulin. Biochem. Biophys. Res. Commun. 114(1), 50-56 (1983). 5.Barnette, M.S.,Daly, R. and Weiss, B. Inhibition of calmodulin activity by insect venom peptides. Biochem. Pharmacol. 32(19), 2929-2933 (1983). 6.Hilchie, A.L.,Sharon, A.J.,Haney, E.F., et al. Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma. Biochim Biophys. Acta. 1858(12), 3195-3204 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1478.9 |
| 分子式 | C70H131N19O15 |
| CAS号 | 72093-21-1 |
| 稳定性 | ≥ 2 years |
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