| 货号 | 19861-500mg |
| 描述 | Paeoniflorin is a monoterpene glycoside first isolated from the roots of peony. It has diverse cellular actions, including modulating NMDA and TRPV1 receptors.1,2 Paeoniflorin is reported to inhibit testosterone synthesis and stimulate aromatase activity.3 It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-9 and ERK signaling.4,5,6 Presumably through some of these actions, paeoniflorin has analgesic and anti-inflammatory actions in mice. |
| 别名 | NSC 178886; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, Y.-F.,Lee, M.-M.,Fang, H.-L., et al. Paeoniflorin inhibits excitatory amino acid agonist-and high-dose morphine-induced nociceptive behavior in mice via modulation of N-methyl-D-aspartate receptors. BMC Complement.Altern.Med. 16(1), (2016). 2.Han, F.,Zhou, D.,Yin, X., et al. Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway. Cell Biosci. 6:37, (2016). 3.Takeuchi, T.,Nishii, O.,Okamura, T., et al. Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. The American Journal of Chinese Medicine 19(1), 73-78 (1991). 4.Wang, P.,Wang, W.,Shi, Q., et al. Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis‑induced acute renal injury. Mol.Med.Rep. 14(2), 1123-1131 (2016). 5.Yang, N.,Cui, H.,Han, F., et al. Paeoniflorin inhibits human pancreatic cancer cell apoptosis via suppression of MMP-9 and ERK signaling. Oncol.Lett. 12(2), 1471-1476 (2016). 6.Zhou, J.,Wang, L.,Wang, J., et al. Paeoniflorin and albiflorin attenuate neuropathic pain via MAPK pathway in chronic constriction injury rats. Evid.Based Complement.Alternat.Med 2016:8082753, (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 480.5 |
| 分子式 | C23H28O11 |
| CAS号 | 23180-57-6 |
| 稳定性 | ≥ 2 years |
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