Cdk4 Inhibitor
货号：
17648-5mg 基本售价：
5782.0 元 规格：
5 mg
产品信息
概述| 货号 | 17648-5mg |
| 描述 | Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 μM.1 It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A.1 This compound has been shown to inhibit HCT116 and NCI-H460 tumor cell growth (IC50s< 3.0 μM) by blocking retinoblastoma protein phosphorylation and inducing G1 cell cycle arrest.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhu, G.,Conner, S.E.,Zhou, X., et al. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. Journal of Medicinal Chemistry 46(11), 2027-2030 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 404.2 |
| 分子式 | C20H10BrN3O2 |
| CAS号 | 546102-60-7 |
| 稳定性 | ≥ 2 years |
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