| 货号 | 15998-50mg |
| 描述 | In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A(MT1) and MT1B(MT2).1 Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A(Ki values are = 10-27 and 158-513 nM, respectively).2,3,4 Luzindole is used both in vitroandin vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.5,6,2 |
| 别名 | N-0774; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chan, K.H. and Wong, Y.H. A molecular and chemical perspective in defining melatonin receptor subtype selectivity. International Journal of Molecular Sciences 14(9), 18385-18406 (2013). 2.Teh, M.T. and Sugden, D. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: Lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn-Schmiedebergs Archives of Pharmacology 358(5), 522-528 (1998). 3.Dubocovich, M.L. Luzindole (N-0774): A novel melatonin receptor antagonist. Journal of Pharmacology and Experimental Therapeutics 246(3), 902-910 (1988). 4.Dubocovich, M.L.,Masana, M.I.,Iacob, S., et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedebergs Archives of Pharmacology 355(3), 365-375 (1997). 5.Dubocovich, M.L.,Yun, K.,Al-Ghoul, W.M., et al. Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. The FASEB Journal 12(12), 1211-1220 (1998). 6.Laredo, S.A.,Orr, V.N.,McMackin, M.Z., et al. The effects of exogenous melatonin and melatonin receptor blockade on aggression and estrogen-dependent gene expression in male California mice (Peromyscus californicus). Physiology & Behavior 128, 86-91 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 292.3 |
| 分子式 | C19H20N2O |
| CAS号 | 117946-91-5 |
| 稳定性 | ≥ 2 years |
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