| 货号 | 15549-50mg |
| 描述 | Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation.1,2 The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities.2,3,4 Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moore, C.W. Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. Cancer Research 48(23), 6837-6843 (1988). 2.Hecht, S.M. Bleomycin: New perspectives on the mechanism of action. Journal of Natural Products 63, 158-168 (2000). 3.Kajiwara, K.,Kim, U.H. and Mueller, G.C. Phleomycin, an inhibitor of replication of HeLa cells. Cancer Research 26(2), 233-236 (1966). 4.Allen, T.E.,Brown, D.J.,Cowden, W.B., et al. Amplification of the antitumor activity of phleomycins in rats and mice by heterocyclic analogues of purines. J.Antibiot.(Tokyo) 37(4), 376-383 (1984). 5.Gatignol, A.,Baron, M. and Tiraby, G. Phleomycin resistance encoded by the ble gene from transposon Tn 5 as a dominant selectable marker in Saccharomyces cerevisiae. Mol.Gen.Genet. 207(2-3), 342-348 (1987). 6.Wenzel, T.J.,Migliazza, A.,Steensma, H.Y., et al. Efficient selection of phleomycin-resistant Saccharomyces cerevisiae transformants. Yeast 8(8), 667-668 (1992). 7.Vickers, C.E.,Bydder, S.F. and Nielsen, L.K. Dual gene expression cassette vectors with antibiotic selection markers for engineering in Saccharomyces cerevisiae. Microb.Cell Fact. 12, 96 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1526.5 |
| 分子式 | C55H85N20O21S2Cu • HCl |
| CAS号 | 11006-33-0 |
| 稳定性 | ≥ 2 years |
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