| 货号 | 15044-50mg |
| 描述 | Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro(IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM).1,2 It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes.3 Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mayer, T.U.,Kapoor, T.M.,Haggarty, S.J., et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974 (1999). 2.Klein, E.,DeBonis, S.,Thiede, B., et al. New chemical tools for investigating human mitotic kinesin Eg5. Bioorganic & Medicinal Chemistry 15(19), 6474-6488 (2007). 3.Kapoor, T.M.,Mayer, T.U.,Coughlin, M.L., et al. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin Eg5. Journal of Cell Biology 150(5), 975-988 (2000). 4.Good, J.A.D.,Skoufias, D.A. and Kozielski, F. Elucidating the functionality of kinesins: An overview of small molecule inhibitors. Seminars in Cell & Developmental Biology 22(9), 935-945 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 292.4 |
| 分子式 | C14H16N2O3S |
| CAS号 | 329689-23-8 |
| 稳定性 | ≥ 2 years |
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