| 货号 | 14616-100mg |
| 描述 | Dorzolamide is an inhibitor of carbonic anhydrase, inhibiting human isoforms II, V, VI, IX, XII, XIII, and XIV with Ki values between 3.5 and 52 nM.1,2,3 It less effectively inhibits human carbonic anhydrases I, III, and IV (Ki = 50, 8, and 8.5 μM, respectively).1 Topically applied inhibitors of carbonic anhydrase, including dorzolamide, are commonly used to treat glaucoma.4,5 |
| 别名 | L-671,152;MK-507; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Supuran, C.T. and Scozzafava, A. Carbonic anhydrases as targets for medicinal chemistry. Bioorganic & Medicinal Chemistry 15(13), 4336-4350 (2007). 2.Greer, J.,Erickson, J.W.,Baldwin, J.J., et al. Application of the three-dimensional structures of protein target molecules in structure-based drug design. Journal of Medicinal Chemistry 37(8), 1035-1054 (1994). 3.Hunt, C.A.,Mallorga, P.J.,Michelson, S.R., et al. 3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors. Journal of Medicinal Chemistry 37(2), 240-247 (1994). 4.Loftsson, T.,Jansook, P. and Stefánsson, E. Topical drug delivery to the eye: Dorzolamide. Acta.Ophthalmol. 90, 603-608 (2012). 5.Cheng, J.W.,Cheng, S.W.,Gao, L.D., et al. Intraocular pressure-lowering effects of commonly used fixed-combination drugs with Timolol: A systematic review and meta-analysis. PLoS One 7(9), 45079 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.9 |
| 分子式 | C10H16N2O4S3 • HCl |
| CAS号 | 130693-82-2 |
| 稳定性 | ≥ 2 years |
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